5 Types of Hepatitis: A, B, C, D, E

There are 5 different hepatitis viruses (A, B, C, D, and E). Each belongs to its own virus family, and each is genomically distinct, having unique replication strategies. Along with differences in transience, they differ in their mechanism for infection. Learn more about them below.


Hepatitis A Virus (HAV)

HAV is transient and transmitted oro-faecally. Exposure typically happens by eating or drinking something contaminated with the virus. A sick person will then pass it through their stool. It’s rampant in countries with poor sanitation systems, where infected stool can contaminate an entire water supply. You can reduce your risk of infection by using good hygiene practices and avoiding contaminated food and water (drink bottled water, for instance). The best defense is to have the HAV vaccine. If you’re traveling, you definitely need this vaccination.

 

Hepatitis B Virus (HBV)

HBV is transient or chronic and transmitted by the parenteral route, meaning it moves through blood and blood products. This is the most prevalent hepatitis virus known to become chronic, meaning it will stay with you long-term. It has a double shell. The outer shell is like an envelope, and the inner shell contains the virus. To diagnose this type, a blood test is needed. Presence increases a person’s risk for liver cancer.

 

Hepatitis C Virus (HCV)

HCV is transient or chronic and transmitted by the parenteral route. Most infections of this type are chronic. Variants of HCV possess many similarities in their genomic structure and replication strategy. Symptoms of this type are similar to the other strains. Like HBV, a blood test is needed for diagnosis, and positive results increase a person’s risk for liver cancer.

Hepatitis D Virus (HDV)

HDV is transient or chronic and transmitted by the parenteral route. Unlike HBV, HDV doesn’t encode an envelope protein for transmission. This virus causes swelling of the liver. The best way to prevent it is to avoid blood and bodily fluid exposure, as well as being vaccinated.

Hepatitis E Virus (HEV)

HEV is transient and transmitted oro-faecally. In developing countries, this type is responsible for major outbreaks of acute hepatitis. One of its unique characteristics is high mortality among pregnant women in the third trimester. It’s not common in the U.S. It causes the liver to swell but doesn’t cause any long-term damage.


To learn more about all types of this virus, enroll in hepatitis CME (continuing medical education) courses.

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